A phase I study recommended carboplatin (CBDCA, area under the curve = 5) plus pemetrexed (PEM, 500 mg/m 2) for elderly patients (≥75-years old) with non-squamous non-small cell lung cancer (NSCLC). Carboplatin, Paclitaxel, and Radiation Therapy With or Without This randomized phase III trial is studying carboplatin, paclitaxel, radiation therapy, and thalidomide to see how well they work compared to carboplatin, paclitaxel, and radiation therapy alone in treating patients with newly diagnosed stage III non-small cell lung cancer.
For patients who previously DID NOT receive chemotherapy (untreated), a target AUC of 7 (range: 6-8) mg/mL per minute has been recommended when carboplatin is used alone. Carboplatin - Wikipedia The typical area under the curve (AUC) for carboplatin ranges from 3-7 mg/ml/min. History. Carboplatin was discovered at Michigan State University, and developed at the Institute of Cancer Research in London. Phase I/II Study of Carboplatin and Weekly Paclitaxel for A total of 26 patients were enrolled in this study through 6 dose escalations. The MTD was determined to be level 6 (CBDCA AUC=6, PTX 100 mg/m 2), at which G3 infection occurred in 2 patients. No DLT except for G3 infection was observed through the study, and neutropenia, neuropathy and myalgia were mild.
Chemo-naïve stage IIIB/IV or postoperative recurrent SCC pts were randomly assigned to receive either cisplatin (80 mg/m2) on day 1 plus gemcitabine (1000 mg/m2) on days 1, 8 every 3 weeks or CBDCA (AUC 6 mg/ml/min) on day 1 plus nab-PTX (75 mg/m2) on days 1, 8, 15 every 3 weeks.
Carboplatin - Wikipedia The typical area under the curve (AUC) for carboplatin ranges from 3-7 mg/ml/min. History.
Background: Carboplatin (CBDCA) was classified moderate emetic risk. 5-HT3 antagonist and corticosteroid had a great efficacy in patients (pts) treated with CBD We use cookies to enhance your experience on our website.By continuing to use our website, you are agreeing to our use of cookies.
Investigation of tolerability and quality of life for The measured AUC of CBDCA in the first cycle was 5.96 mg/mL min, which was 19.2% higher than the target AUC (Fig. 1a). Consequently, grade 4 neutropenia and grade 3 thrombocytopenia were observed, according to the National Cancer Institute’s Common Toxicity Criteria for Adverse Events version 4.0 (Table 1). Japanese Gynecologic Oncology Group DTX: 70mg/m2, CBDCA: AUC=6 GOG finally concluded, the adjuvant chemotherapy of more than TC3 cycle shows to be not necessary. Results of JGOG questionnaire 0 50 100 150 200 250 300 350 IC(a),(1),(2) Performed Lymphadenectomy Peritoneal biopsy Informed con O2–055RANDOMIZED PHASE III TRIAL OF APREPITANT COMPARED WITH Background: Carboplatin (CBDCA) was classified moderate emetic risk.
A median of 4 cycles were administered (range, 1-7 cycles). Three patients discontinued treatment due to Chemotherapy for advanced non-small cell lung cancer with a focus The CA031 joint international trial was a Phase III randomized controlled trial to verify the superiority of the response rate to CBDCA (AUC 6 on day 1) + nab-PTX (100 mg/m 2 weekly, 3-week cycle (nab-PTX arm), compared to CBDCA (AUC 6 on day 1) + solvent-based (sb)-PTX (200 mg/m 2 on day 1), 3-week cycle, as the reference arm. [Probability of the combination use of cisplatin and carboplatin CDDP and CBDCA, which are AUC dependent drugs, have shown different side effects in previous clinical practice. And the combination effect of both drugs is more than additive effect at the AUC ratios of free Pt of 3.2, 6.5, 13.1 (CBDCA/CDDP).
P1.01-33 Randomized Phase 2 Study Comparing CBDCA+PTX+BEV and Treatment-naïve patients with advanced or recurrent EGFR/ALK-negative non-Sq NSCLC from 55 sites across Japan were randomly assigned in a 2:1 ratio to either CDDP+PEM+BEV (4 cycles of CDDP [75 mg/m 2] + PEM [500 mg/m 2] + BEV [15 mg/kg] q3wk, followed by maintenance PEM + BEV q3wk until progression) or CBDCA+PTX+BEV (4 cycles of CBDCA [AUC 6] + PTX [200 mg/m 2] + BEV q3wk, followed by MO2-13-1Randomized phase II trial of CBDCA+nab-PTX vs CDDP+GEM in Chemo-naïve stage IIIB/IV or postoperative recurrent SCC pts were randomly assigned to receive either cisplatin (80 mg/m2) on day 1 plus gemcitabine (1000 mg/m2) on days 1, 8 every 3 weeks or CBDCA (AUC 6 mg/ml/min) on day 1 plus nab-PTX (75 mg/m2) on days 1, 8, 15 every 3 weeks. Investigation of tolerability and quality of life for The measured AUC of CBDCA in the first cycle was 5.96 mg/mL min, which was 19.2% higher than the target AUC (Fig. 1a).
Carboplatin dose Calculator from MedicineWorld.Org Carboplatin dose calculator from Medicineworld.Org. Your gateway to medical information. Information for patients, resources for physicians. Open access Protocol Clinical trial protocol of doublet therapy DEX in CBDCA combination therapy with area under curve (AUC) ≥5 mg/mL/min for the prevention of nausea and vomiting in patients with thoracic cancer. Methods and analysis This is an open-label, single-arm, multicentre, phase II trial. Patients who receive CBDCA-based therapies (AUC ≥5) and have never been A phase II study of pemetrexed plus carboplatin followed by Abstract.
The primary endpoint was an overall response rate (ORR), and secondary endpoints were progression‐free survival (PFS), overall survival (OS), and toxicity. Randomized phase II trial of CBDCA+nab-PTX vs CDDP+GEM in Methods. Chemo-naïve stage IIIB/IV or postoperative recurrent SCC pts were randomly assigned to receive either cisplatin (80 mg/m2) on day 1 plus gemcitabine (1000 mg/m2) on days 1, 8 every 3 weeks or CBDCA (AUC 6 mg/ml/min) on day 1 plus nab-PTX (75 mg/m2) on days 1, 8, 15 every 3 weeks. P1.08-006 Phase I/II Study of Carboplatin, nab-paclitaxel, and Concurrent chemoradiotherapy with nab-PTX 50 mg/m 2 and CBDCA AUC 2 was the recommended dose. We will report the latest efficacy and safety profile of the present therapy.
）= （mg/body）. 血清クレアチニン値の補正（+0.2）あり： TJ 療法は TXL（200 mg/m2）および CBDCA（target. AUC: 6 mg/mL/min）をいずれも第 1 日目に点滴静注投. 与とし，3 週間隔で繰り返す投与スケジュールで施行し.
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Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2/p-2 ☑ Y. Key:OLESAACUTLOWQZ-UHFFFAOYSA-L ☑ Y. ☒ N ☑ Y (what is this?) (verify). Carboplatin, sold under the trade name Paraplatin among others, is a chemotherapy The typical area under the curve (AUC) for carboplatin ranges from 3-7 mg/ml/min 1 Jan 2014 SYNONYM(S): CBDCA, JM8, NSC 241240. COMMON 2- to 3-fold variability in AUC with BSA-based dosing.5,6 Variability can be reduced. 5 days ago CBDCA plus paclitaxel (PTX) adjuvant chemotherapy showed a In the CA 031 trial, CBDCA (AUC=6 mg/mL/min) was administered on day 1 In the leading cohort, the first 6 patients were treated with CBDCA (AUC=6) and PEM (500 mg/m2), and the toxicities were evaluated. Accordingly, the dose of ORR, overall response rate; CBDCA, carboplatin.